What are the causes of Addison’s Disease?
The main cause of Addison’s Disease is damage to the adrenal glands. The disease is classified as either primary and secondary.
What are Addison’s Disease risk factors?
Your risk can increase if you:
Addison’s is a rare disease where the adrenal glands don’t produce enough of the hormones cortisol or aldosterone. The adrenal glands are located above the kidneys. This insufficiency can be caused by the glands not functioning properly or by damage to the adrenal glands. When you are in a stressful situation, your adrenal glands produce cortisol. Aldosterone works to control and regulate sodium and potassium. The adrenal gland also produces androgens or sex hormones.
Scientists don’t know if it can be inherited, or caused by the genes you inherit. However, if you have a family member with Addison’s Disease you have a higher risk of developing it.
While Addison’s disease cannot be cured, with prompt diagnosis and treatment the patient can have a normal life span and lead an active life. The symptoms can be treated with medication and changes in your lifestyle. Addison’s Disease patients often have periods of fatigue, or may have other associated health conditions. Today, the prognosis for Addison’s Disease is relatively positive.
The chief difference between Addison’s Disease and Cushing’s Syndrome patients is their levels of the hormone cortisol. Addison’s Disease is a lack of sufficient cortisol, and Cushing’s Syndrome occurs when there’s too much cortisol.
The main cause of Addison’s Disease is damage to the adrenal glands. The disease is classified as either primary and secondary.
Your risk can increase if you:
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Symptoms of Addison’s Disease most often develop between the ages of 30 and 50. Symptoms are similar to other autoimmune diseases and can include:
Called Addisonian crisis, acute adrenal failure is the sudden symptoms that occur when untreated Addison’s Disease causes an extremely low level of cortisol. The symptoms of shock that occur with Addisonian crisis can be life-threatening. The patient must get medical attention immediately.
Addisonian crisis can cause any of the following symptoms:
After your doctor asks about your medical history and your symptoms, you may have some of the following tests:
Since Addison’s Disease cannot be cured, treatment focuses on symptom management. Your treatment plan will likely include:
Medically reviewed by:
Dr. Seigel is a board certified Endocrinologist. He completed his residency in internal medicine and fellowship in endocrinology, diabetes and metabolism at the University Of Pittsburgh Medical Center in 2011 and 2013.
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